IL-21 and IL-21 receptor expression in lymphocytes and neurons in multiple sclerosis brain.

Journal article

IL-17-producing CD4(+) T cells (Th-17) contribute to the pathogenesis of experimental autoimmune encephalomyelitis and are associated with active disease in multiple sclerosis (MS). In addition to IL-17, Th-17 cells can also express IL-21, IL-22, and IL-6 under Th-17-polarizing conditions (IL-6 and transforming growth factor-β). In this study we investigated IL-21 and IL-21 receptor (IL-21R) expression in MS lesions by in situ hybridization and immunohistochemistry. We detected strongly IL-21...

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Authors: Tzartos, J; Craner, M; Friese, M; Jakobsen, K; Newcombe, J

• Publication status: Published
• Journal: American journal of pathology
• Volume: 178
• Issue: 2
• Pages: 794-802
• Publication date: 2011-02-01
• DOI: 10.1016/j.ajpath.2010.10.043
• EISSN: 1525-2191
• ISSN: 0002-9440
• Language: English
• Keywords: Antigens, CD19; RNA, Messenger; CD4-Positive T-Lymphocytes; Chronic Disease; CD8-Positive T-Lymphocytes; Interleukins; Neurons; Up-Regulation; Brain; Humans; B-Lymphocytes; Acute Disease; Interleukin-21 Receptor alpha Subunit; Multiple Sclerosis