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Journal article

Identification of a heteromeric interaction that influences the rectification, gating, and pH sensitivity of Kir4.1/Kir5.1 potassium channels.

Abstract:

Heteromultimerization between different potassium channel subunits can generate channels with novel functional properties and thus contributes to the rich functional diversity of this gene family. The inwardly rectifying potassium channel subunit Kir5.1 exhibits highly selective heteromultimerization with Kir4.1 to generate heteromeric Kir4.1/Kir5.1 channels with unique rectification and kinetic properties. These novel channels are also inhibited by intracellular pH within the physiological r...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m306596200

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Physics
Sub department:
Condensed Matter Physics
Role:
Author
Journal:
Journal of biological chemistry More from this journal
Volume:
278
Issue:
44
Pages:
43533-43540
Publication date:
2003-10-01
DOI:
EISSN:
1083-351X
ISSN:
0021-9258

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