Journal article icon

Journal article

Large-scale structural analysis of the classical human protein tyrosine phosphatome.

Abstract:

Protein tyrosine phosphatases (PTPs) play a critical role in regulating cellular functions by selectively dephosphorylating their substrates. Here we present 22 human PTP crystal structures that, together with prior structural knowledge, enable a comprehensive analysis of the classical PTP family. Despite their largely conserved fold, surface properties of PTPs are strikingly diverse. A potential secondary substrate-binding pocket is frequently found in phosphatases, and this has implications...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1016/j.cell.2008.11.038

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Author
Journal:
Cell More from this journal
Volume:
136
Issue:
2
Pages:
352-363
Publication date:
2009-01-01
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
Language:
English
Keywords:
Pubs id:
pubs:20499
UUID:
uuid:6a02ed7b-0400-4e0f-8adf-ab9888c0229a
Local pid:
pubs:20499
Source identifiers:
20499
Deposit date:
2012-12-19

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP