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Journal article

Multiple instances of ancient balancing selection shared between humans and chimpanzees.

Abstract:

Instances in which natural selection maintains genetic variation in a population over millions of years are thought to be extremely rare. We conducted a genome-wide scan for long-lived balancing selection by looking for combinations of SNPs shared between humans and chimpanzees. In addition to the major histocompatibility complex, we identified 125 regions in which the same haplotypes are segregating in the two species, all but two of which are noncoding. In six cases, there is evidence for a...

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Publication status:
Published

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Publisher copy:
10.1126/science.1234070

Authors


Leffler, EM More by this author
Pfeifer, S More by this author
Ségurel, L More by this author
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Publisher:
American Association for the Advancement of Science
Journal:
Science (New York, N.Y.)
Volume:
339
Issue:
6127
Pages:
1578-1582
Publication date:
2013-03-05
DOI:
EISSN:
1095-9203
ISSN:
0036-8075
URN:
uuid:69f1d764-3d93-4cff-91b9-201b450fe69f
Source identifiers:
388180
Local pid:
pubs:388180

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