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Journal article

Methodologic issues in clinical trials for prevention or risk reduction in osteoarthritis.

Abstract:

The design and execution of prevention trials for OA have methodological issues that are distinct from trials designed to impact prevalent disease. Disease definitions and their precise and sensitive measurement, identification of high-risk populations, the nature of the intervention (pharmaceutical, nutraceutical, behavioral) and its potential pleiotropic impacts on other organ systems are critical to consider. Because prevention trials may be prolonged, close attention to concomitant life c...

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Publication status:
Published

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Publisher copy:
10.1016/j.joca.2010.10.031

Authors


Journal:
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society More from this journal
Volume:
19
Issue:
5
Pages:
500-508
Publication date:
2011-05-01
DOI:
EISSN:
1522-9653
ISSN:
1063-4584
Language:
English
Keywords:
Pubs id:
pubs:149886
UUID:
uuid:69efa83f-853b-4949-9d03-841d82c973cb
Local pid:
pubs:149886
Source identifiers:
149886
Deposit date:
2013-11-17

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