Methodologic issues in clinical trials for prevention or risk reduction in osteoarthritis.

Journal article

The design and execution of prevention trials for OA have methodological issues that are distinct from trials designed to impact prevalent disease. Disease definitions and their precise and sensitive measurement, identification of high-risk populations, the nature of the intervention (pharmaceutical, nutraceutical, behavioral) and its potential pleiotropic impacts on other organ systems are critical to consider. Because prevention trials may be prolonged, close attention to concomitant life c...

Expand abstract

Authors: Jordan, J; Sowers, M; Messier, S; Bradley, J; Arangio, G

• Publication status: Published
• Journal: Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society
• Volume: 19
• Issue: 5
• Pages: 500-508
• Publication date: 2011-05-01
• DOI: 10.1016/j.joca.2010.10.031
• EISSN: 1522-9653
• ISSN: 1063-4584
• Language: English
• Keywords: Ethics, Research; Osteoarthritis; Female; Knee Injuries; Adult; Middle Aged; Risk Reduction Behavior; Clinical Trials as Topic; Humans; Research Design; Osteoarthritis, Knee; Overweight; Male; Young Adult