- Abstract:
-
In the genetic analysis of common, multifactorial diseases, such as type 1 diabetes, true positive irrefutable linkage and association results have been rare to date. Recently, it has been reported that a single nucleotide polymorphism (SNP), 1858C>T, in the gene PTPN22, encoding Arg620Trp in the lymphoid protein tyrosine phosphatase (LYP), which has been shown to be a negative regulator of T-cell activation, is associated with an increased risk of type 1 diabetes. Here, we have replicated...
Expand abstract - Publisher copy:
- 10.2337/diabetes.53.11.3020
-
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- Journal:
- Diabetes
- Volume:
- 53
- Issue:
- 11
- Pages:
- 3020-3023
- Publication date:
- 2004-11-05
- DOI:
- EISSN:
-
1939-327X
- ISSN:
-
0012-1797
- URN:
-
uuid:69e9fb2c-90f7-495e-9827-b845b88ebfec
- Source identifiers:
-
176446
- Local pid:
- pubs:176446
- Copyright date:
- 2004
Journal article
Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus.
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