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Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus.

Abstract:

In the genetic analysis of common, multifactorial diseases, such as type 1 diabetes, true positive irrefutable linkage and association results have been rare to date. Recently, it has been reported that a single nucleotide polymorphism (SNP), 1858C>T, in the gene PTPN22, encoding Arg620Trp in the lymphoid protein tyrosine phosphatase (LYP), which has been shown to be a negative regulator of T-cell activation, is associated with an increased risk of type 1 diabetes. Here, we have replicated...

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Publisher copy:
10.2337/diabetes.53.11.3020

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Journal:
Diabetes
Volume:
53
Issue:
11
Pages:
3020-3023
Publication date:
2004-11-05
DOI:
EISSN:
1939-327X
ISSN:
0012-1797
URN:
uuid:69e9fb2c-90f7-495e-9827-b845b88ebfec
Source identifiers:
176446
Local pid:
pubs:176446

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