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Vitamin D receptor polymorphisms and susceptibility to tuberculosis in West Africa: a case-control and family study.

Abstract:

Vitamin D receptor (VDR) gene polymorphisms have been implicated in susceptibility to tuberculosis (TB), but reports have been inconsistent. We genotyped the VDR single-nucleotide polymorphisms (SNPs) FokI, BsmI, ApaI, and TaqI in 1139 case patients and control subjects and 382 families from The Gambia, Guinea, and Guinea-Bissau. The transmission-disequilibrium test on family data showed a significant global association of TB with SNP combinations FokI-BsmI-ApaI-TaqI and FokI-ApaI that were d...

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Publication status:
Published

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Publisher copy:
10.1086/424462

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Journal:
Journal of infectious diseases
Volume:
190
Issue:
9
Pages:
1631-1641
Publication date:
2004-11-01
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
Source identifiers:
32875

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