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Role of a BRCT domain in the interaction of DNA ligase III-alpha with the DNA repair protein XRCC1.

Abstract:

The BRCT domain (for BRCA1 carboxyl terminus) is a protein motif of unknown function, comprising approximately 100 amino acids in five conserved blocks denoted A-E. BRCT domains are present in the tumour suppressor protein BRCA1 [1-3], and the domain is found in over 40 other proteins, defining a superfamily that includes DNA ligase III-alpha and the essential human DNA repair protein XRCC1. DNA ligase III-alpha and XRCC1 interact via their carboxyl termini, close to or within regions that co...

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Publication status:
Published

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Journal:
Current biology : CB
Volume:
8
Issue:
15
Pages:
877-880
Publication date:
1998-07-05
DOI:
EISSN:
1879-0445
ISSN:
0960-9822
URN:
uuid:69e363fc-9ec9-4c8d-9b2c-51b0a2e00f87
Source identifiers:
20858
Local pid:
pubs:20858

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