Aberrant selection and function of invariant NKT cells in the absence of AP-1 transcription factor Fra-2.

Journal article

The transcription factors mediating the development of CD1d-restricted invariant NKT (iNKT) cells remain incompletely described. Here, we show that loss of the AP-1 transcription factor Fra-2 causes a marked increase in the number of both thymic and peripheral iNKT cells, without affecting the development of other T-lineage cells. The defect is cell-autonomous and is evident in the earliest iNKT precursors. We find that iNKT cells expressing the lower affinity TCRVbeta8 are proportionally ove...

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Authors: Lawson, V; Maurice, D; Silk, J; Cerundolo, V; Weston, K

• Publication status: Published
• Journal: Journal of Immunology
• Volume: 183
• Issue: 4
• Pages: 2575-2584
• Publication date: 2009-08-01
• DOI: 10.4049/jimmunol.0803577
• EISSN: 1550-6606
• ISSN: 0022-1767
• Language: English
• Keywords: Cell Proliferation; Molecular Sequence Data; Mice, Transgenic; Fos-Related Antigen-2; Thymus Gland; Interleukin-4; Gene Deletion; Mice; Natural Killer T-Cells; Transcription Factor AP-1; Cell Differentiation; Mice, Inbred C57BL; Mice, Knockout; Interleukin-2; Amino Acid Sequence; Animals