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The structural basis for catalysis and substrate specificity of a rhomboid protease.

Abstract:

Rhomboids are intramembrane proteases that use a catalytic dyad of serine and histidine for proteolysis. They are conserved in both prokaryotes and eukaryotes and regulate cellular processes as diverse as intercellular signalling, parasitic invasion of host cells, and mitochondrial morphology. Their widespread biological significance and consequent medical potential provides a strong incentive to understand the mechanism of these unusual enzymes for identification of specific inhibitors. In t...

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Publication status:
Published

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Publisher copy:
10.1038/emboj.2010.243

Authors


Journal:
EMBO journal More from this journal
Volume:
29
Issue:
22
Pages:
3797-3809
Publication date:
2010-11-01
DOI:
EISSN:
1460-2075
ISSN:
0261-4189
Language:
English
Keywords:
Pubs id:
pubs:356043
UUID:
uuid:69d374bb-c0a3-4ae0-ab09-b652c86fb443
Local pid:
pubs:356043
Source identifiers:
356043
Deposit date:
2013-11-16

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