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Emergency of primary NNRTI resistance mutations without antiretroviral selective pressure in a HAART-treated child

Abstract:

Objective: The use of antiretrovirals (ARV) during pregnancy has drastically reduced the rate of the human immunodeficiency virus perinatal transmission (MTCT). As a consequence of widespread ARV use, transmission of drug resistant strains from mothers to their babies is increasing. Ultra-sensitive PCR techniques have permitted the quantification of minority viral populations, but little is known about the transmission of drug-resistant HIV-1 minority population in the setting of MTCT. Method...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0004806

Authors


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Institution:
"Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil", "Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil"
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Institution:
"Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil"
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Institution:
"NCI-Frederick, Maryland, USA", "SAIC-Frederick, Maryland, USA"
Department:
Basic Science Program
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Institution:
University of Oxford
Department:
Mathematical,Physical & Life Sciences Division - Zoology
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Institution:
"Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil"
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National Institutes of Health More from this funder
Brazilian Ministry of Health More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS ONE Journal website
Volume:
4
Issue:
3
Pages:
Article: e4806
Publication date:
2009-03-05
DOI:
EISSN:
1932-6203
URN:
uuid:69c7aa43-98e5-473a-a837-b42e845d29ea
Local pid:
ora:2830

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