Basigin is a receptor essential for erythrocyte invasion by Plasmodium falciparum.

Journal article

Erythrocyte invasion by Plasmodium falciparum is central to the pathogenesis of malaria. Invasion requires a series of extracellular recognition events between erythrocyte receptors and ligands on the merozoite, the invasive form of the parasite. None of the few known receptor-ligand interactions involved are required in all parasite strains, indicating that the parasite is able to access multiple redundant invasion pathways. Here, we show that we have identified a receptor-ligand pair that i...

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Authors: Crosnier, C; Bustamante, L; Bartholdson, S; Bei, A; Theron, M

• Publication status: Published
• Journal: Nature
• Volume: 480
• Issue: 7378
• Pages: 534-537
• Publication date: 2011-12-01
• DOI: 10.1038/nature10606
• EISSN: 1476-4687
• ISSN: 0028-0836
• Language: English
• Keywords: Models, Molecular; Gene Knockdown Techniques; Humans; Plasmodium falciparum; Protein Structure, Tertiary; Host-Parasite Interactions; Antigens, CD147; Erythrocytes