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Th cells act via two synergistic pathways to promote antiviral CD8+ T cell responses.

Abstract:

The mechanisms of how Th cells promote CD8(+) T cell responses during viral infections are largely unknown. In this study, we unraveled the mechanisms of T cell help for CD8(+) T cell responses during vaccinia virus infection. Our results demonstrate that Th cells promote vaccinia virus-specific CD8(+) T cell responses via two interconnected synergistic pathways: First, CD40L expressed by activated CD4(+) T cells instructs dendritic cells to produce bioactive IL-12p70, which is directly sense...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.1001990

Authors


Ehlert, AK More by this author
Spörri, R More by this author
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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
185
Issue:
9
Pages:
5188-5197
Publication date:
2010-11-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:69b0a4bf-027a-44b8-bb26-16c62a41dc78
Source identifiers:
422329
Local pid:
pubs:422329

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