Journal article
Th cells act via two synergistic pathways to promote antiviral CD8+ T cell responses.
- Abstract:
-
The mechanisms of how Th cells promote CD8(+) T cell responses during viral infections are largely unknown. In this study, we unraveled the mechanisms of T cell help for CD8(+) T cell responses during vaccinia virus infection. Our results demonstrate that Th cells promote vaccinia virus-specific CD8(+) T cell responses via two interconnected synergistic pathways: First, CD40L expressed by activated CD4(+) T cells instructs dendritic cells to produce bioactive IL-12p70, which is directly sense...
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- Publication status:
- Published
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- Publisher copy:
- 10.4049/jimmunol.1001990
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Authors
Bibliographic Details
- Journal:
- Journal of immunology (Baltimore, Md. : 1950)
- Volume:
- 185
- Issue:
- 9
- Pages:
- 5188-5197
- Publication date:
- 2010-11-05
- DOI:
- EISSN:
-
1550-6606
- ISSN:
-
0022-1767
- URN:
-
uuid:69b0a4bf-027a-44b8-bb26-16c62a41dc78
- Source identifiers:
-
422329
- Local pid:
- pubs:422329
Item Description
- Language:
- English
- Keywords:
Terms of use
- Copyright date:
- 2010
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