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Identification of a novel family of presenilin homologues.

Abstract:

Presenilin 1 and presenilin 2 are polytopic membrane proteins, whose genes are mutated in some individuals with Alzheimer's disease. Presenilins have been shown to influence limited proteolysis of amyloid beta protein precursor (APP), Notch and ErbB4, and have been proposed to be gamma-secretases that perform the terminal cleavage of APP. In this model, two conserved and apparently intramembranous aspartic acids participate in catalysis. Highly sequence-similar presenilin homologues are known...

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Publisher copy:
10.1093/hmg/11.9.1037

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Journal:
Human molecular genetics More from this journal
Volume:
11
Issue:
9
Pages:
1037-1044
Publication date:
2002-05-01
DOI:
EISSN:
1460-2083
ISSN:
0964-6906
Language:
English
Keywords:
Pubs id:
pubs:238110
UUID:
uuid:69a6aa10-84ae-4be2-a334-7cc9934cc2ee
Local pid:
pubs:238110
Source identifiers:
238110
Deposit date:
2013-11-16

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