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Unraveling the signaling pathways promoting fibrosis in Dupuytren's disease reveals TNF as a therapeutic target.

Abstract:

Dupuytren's disease is a very common progressive fibrosis of the palm leading to flexion deformities of the digits that impair hand function. The cell responsible for development of the disease is the myofibroblast. There is currently no treatment for early disease or for preventing recurrence following surgical excision of affected tissue in advanced disease. Therefore, we sought to unravel the signaling pathways leading to the development of myofibroblasts in Dupuytren's disease. We charact...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.1301100110

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
110
Issue:
10
Pages:
E928-E937
Publication date:
2013-03-01
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Source identifiers:
387186

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