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Journal article

Host selection of microbiota via differential adhesion

Abstract:

The host epithelium is the critical interface with microbial communities, but the mechanisms by which the host regulates these communities are poorly understood. Here we develop the hypothesis that hosts use differential adhesion to select for and against particular members of their microbiota. We use an established computational, individual-based model to study the impact of host factors that regulate adhesion at the epithelial surface. Our simulations predict that host-mediated adhesion can...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.chom.2016.02.021

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Zoology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Zoology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Zoology
Role:
Author
More from this funder
Name:
European Research Council
Funding agency for:
Foster, K
Grant:
242670
More from this funder
Name:
DEFRA
Funding agency for:
Smith, A
Grant:
OD0221
More from this funder
Name:
Biotechnology and Biological Sciences Research Council
Funding agency for:
McLoughlin, K
Smith, A
Grant:
BB/J014427/1
OD0221
Publisher:
Cell Press
Journal:
Cell Host and Microbe More from this journal
Volume:
19
Issue:
4
Pages:
550-559
Publication date:
2016-03-24
Acceptance date:
2016-02-26
DOI:
EISSN:
1934-6069
ISSN:
1931-3128
Language:
English
Pubs id:
pubs:616802
UUID:
uuid:6996d2e2-ca29-4038-a268-8c82e9adc5d0
Local pid:
pubs:616802
Source identifiers:
616802
Deposit date:
2016-05-09

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