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Identification of selective basophil chemoattractants in human nasal polyps as insulin-like growth factor-1 and insulin-like growth factor-2.

Abstract:

In a search for novel leukocyte chemoattractants at sites of allergic inflammation, we found basophil-selective chemoattractant activity in extracts of human nasal polyps. The extracts were fractionated by reverse phase HPLC, and the resulting fractions were tested for leukocyte-stimulating activity using sensitive shape change assays. The basophil-selective activity detected was not depleted by a poxvirus CC-chemokine-binding protein affinity column. This activity was further purified by HPL...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
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Journal:
Journal of Immunology
Volume:
173
Issue:
10
Pages:
6448-6457
Publication date:
2004-11-01
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
Source identifiers:
229379

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