Randomized, open-label trial of primaquine against vivax malaria relapse in Indonesia.

Journal article

Radical cure of Plasmodium vivax infection applies blood schizontocidal therapy against the acute attack and hypnozoitocidal therapy against later relapse. Chloroquine and primaquine have been used for 60 years in this manner. Resistance to chloroquine by the parasite now requires partnering other blood schizontocides with primaquine. However, the safety and efficacy of primaquine against relapse when combined with other drugs have not been demonstrated. This randomized, open-label, and relap...

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Authors: Sutanto, I; Tjahjono, B; Basri, H; Taylor, W; Putri, F

• Publication status: Published
• Journal: Antimicrobial agents and chemotherapy
• Volume: 57
• Issue: 3
• Pages: 1128-1135
• Publication date: 2013-03-01
• DOI: 10.1128/aac.01879-12
• EISSN: 1098-6596
• ISSN: 0066-4804
• Language: English
• Keywords: Artemisinins; Quinine; Male; Primaquine; Adult; Indonesia; Malaria; Drug Therapy, Combination; Drug Resistance; Drug Dosage Calculations; Recurrence; Military Personnel; Drug Administration Schedule; Malaria, Vivax; Humans; Antimalarials; Plasmodium vivax; Quinolines