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Journal article

Induction of cell cycle and NK cell responses by live-attenuated oral vaccines against typhoid fever

Abstract:

The mechanisms by which oral, live-attenuated vaccines protect against typhoid fever are poorly understood. Here, we analyze transcriptional responses after vaccination with Ty21a or vaccine candidate, M01ZH09. Alterations in response profiles were related to vaccine-induced immune responses and subsequent outcome after wild-type Salmonella Typhi challenge. Despite broad genetic similarity, we detected differences in transcriptional responses to each vaccine. Seven days after M01ZH09 vaccinat...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.3389/fimmu.2017.01276

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Institution:
University of Oxford
Department:
Paediatrics
Role:
Author
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Institution:
University of Oxford
Department:
Paediatrics
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Paediatrics
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Paediatrics
Role:
Author
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Grant:
Strategic Translational Award #092661
Emergent BioSolutions More from this funder
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Grant:
Newton Fund MR/M02637X/1
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Grant:
Newton Fund FAPESP, #2012/19278-6 and 2014/50828-8
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Grant:
FP7 Marie Curie Fellowship
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Publisher:
Frontiers Media Publisher's website
Journal:
Frontiers in Immunology Journal website
Volume:
8
Issue:
1276
Publication date:
2017-10-12
Acceptance date:
2017-09-25
DOI:
ISSN:
1664-3224
Pubs id:
pubs:738150
URN:
uri:6989a9a7-61fa-41b9-a097-0af9f1a3b28f
UUID:
uuid:6989a9a7-61fa-41b9-a097-0af9f1a3b28f
Local pid:
pubs:738150
Paper number:
1276

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