- Abstract:
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The mechanisms by which oral, live-attenuated vaccines protect against typhoid fever are poorly understood. Here, we analyze transcriptional responses after vaccination with Ty21a or vaccine candidate, M01ZH09. Alterations in response profiles were related to vaccine-induced immune responses and subsequent outcome after wild-type Salmonella Typhi challenge. Despite broad genetic similarity, we detected differences in transcriptional responses to each vaccine. Seven days after M01ZH09 vaccinat...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 6.4MB)
-
- Publisher copy:
- 10.3389/fimmu.2017.01276
-
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- Grant:
- Newton Fund FAPESP, #2012/19278-6 and 2014/50828-8
- Publisher:
- Frontiers Media Publisher's website
- Journal:
- Frontiers in Immunology Journal website
- Volume:
- 8
- Issue:
- 1276
- Publication date:
- 2017-10-12
- Acceptance date:
- 2017-09-25
- DOI:
- ISSN:
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1664-3224
- Pubs id:
-
pubs:738150
- URN:
-
uri:6989a9a7-61fa-41b9-a097-0af9f1a3b28f
- UUID:
-
uuid:6989a9a7-61fa-41b9-a097-0af9f1a3b28f
- Local pid:
- pubs:738150
- Paper number:
- 1276
- Copyright holder:
- Blohmke et al.
- Copyright date:
- 2017
- Notes:
- © 2017 Blohmke, Hill, Darton, Carvalho-Burger, Eustace, Jones, Schreiber, Goodier, Dougan, Nakaya and Pollard. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Journal article
Induction of cell cycle and NK cell responses by live-attenuated oral vaccines against typhoid fever
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Emergent BioSolutions
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+ São Paulo Research Foundation
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