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3D-structured illumination microscopy provides novel insight into architecture of human centrosomes.

Abstract:

Centrioles are essential for the formation of cilia and flagella. They also form the core of the centrosome, which organizes microtubule arrays important for cell shape, polarity, motility and division. Here, we have used super-resolution 3D-structured illumination microscopy to analyse the spatial relationship of 18 centriole and pericentriolar matrix (PCM) components of human centrosomes at different cell cycle stages. During mitosis, PCM proteins formed extended networks with interspersed ...

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Publisher copy:
10.1242/bio.20122337
Journal:
Biology open More from this journal
Volume:
1
Issue:
10
Pages:
965-976
Publication date:
2012-10-01
DOI:
EISSN:
2046-6390
Language:
English
Keywords:
Pubs id:
pubs:365682
UUID:
uuid:6970cff8-c6bd-4546-9139-bacc722c8038
Local pid:
pubs:365682
Source identifiers:
365682
Deposit date:
2013-11-17

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