Alpha oscillations in the pedunculopontine nucleus correlate with gait performance in parkinsonism

Journal article

The pedunculopontine nucleus, a component of the reticular formation, is topographically organized in animal models and implicated in locomotor control. In Parkinson's disease, pedunculopontine nucleus stimulation is an emerging treatment for gait freezing. Local field potentials recorded from pedunculopontine nucleus electrodes in such patients have demonstrated oscillations in the alpha and beta frequency bands, reactive to self-paced movement. Whether these oscillations are topographically...

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Authors: Thevathasan, W; Pogosyan, A; Hyam, J; Jenkinson, N; Foltynie, T

• Journal: Brain
• Volume: 135
• Issue: 1
• Pages: 148-160
• Publication date: 2012-01-01
• DOI: 10.1093/brain/awr315
• EISSN: 1460-2156
• ISSN: 0006-8950
• Language: English
• Keywords: Parkinson's disease; deep brain stimulation; gait freezing; pedunculopontine nucleus; neuronal oscillations