Sas-6 and Ana2/STIL proteins are required for centriole duplication and the homooligomerisation properties of Sas-6 help establish the ninefold symmetry of the central cartwheel that initiates centriole assembly. Ana2/STIL proteins are poorly conserved, but they all contain a predicted Central Coiled-Coil Domain (CCCD). Here we show that theDrosophilaAna2 CCCD forms a tetramer, and we solve its structure to 0.8 Å, revealing that it adopts an unusual parallel-coil topology. We also solve the s...Expand abstract
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- © 2015, Cottee et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
The homo-oligomerisation of both Sas-6 and Ana2 is required for efficient centriole assembly in flies.
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