Journal article icon

Journal article

The homo-oligomerisation of both Sas-6 and Ana2 is required for efficient centriole assembly in flies.

Abstract:

Sas-6 and Ana2/STIL proteins are required for centriole duplication and the homooligomerisation properties of Sas-6 help establish the ninefold symmetry of the central cartwheel that initiates centriole assembly. Ana2/STIL proteins are poorly conserved, but they all contain a predicted Central Coiled-Coil Domain (CCCD). Here we show that theDrosophilaAna2 CCCD forms a tetramer, and we solve its structure to 0.8 Å, revealing that it adopts an unusual parallel-coil topology. We also solve the s...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.7554/elife.07236

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Expand authors...
Biotechnology and Biological Sciences Research Council More from this funder
Publisher:
eLife Sciences Publications Publisher's website
Journal:
eLife Journal website
Volume:
4
Issue:
MAY
Pages:
e07236
Publication date:
2015-05-05
DOI:
EISSN:
2050-084X
URN:
uuid:696adc0b-1371-4b5e-b330-c59f3d808aa4
Source identifiers:
525235
Local pid:
pubs:525235

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP