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Journal article

The homo-oligomerisation of both Sas-6 and Ana2 is required for efficient centriole assembly in flies.

Abstract:

Sas-6 and Ana2/STIL proteins are required for centriole duplication and the homooligomerisation properties of Sas-6 help establish the ninefold symmetry of the central cartwheel that initiates centriole assembly. Ana2/STIL proteins are poorly conserved, but they all contain a predicted Central Coiled-Coil Domain (CCCD). Here we show that theDrosophilaAna2 CCCD forms a tetramer, and we solve its structure to 0.8 Å, revealing that it adopts an unusual parallel-coil topology. We also solve the s...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.7554/elife.07236

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
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Biotechnology and Biological Sciences Research Council More from this funder
Publisher:
eLife Sciences Publications Publisher's website
Journal:
eLife Journal website
Volume:
4
Issue:
MAY
Pages:
e07236
Publication date:
2015-05-01
Acceptance date:
2015-05-22
DOI:
EISSN:
2050-084X
Source identifiers:
525235
Language:
English
Keywords:
Pubs id:
pubs:525235
UUID:
uuid:696adc0b-1371-4b5e-b330-c59f3d808aa4
Local pid:
pubs:525235
Deposit date:
2016-03-11

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