Ring-closing metathesis as a basis for the construction of aromatic compounds.

Journal article

The use of metathesis, especially in the context of ring-closing metathesis (RCM) to form five- and six-membered rings, is widespread in organic chemistry today. However, there are surprisingly few examples of the reaction being used to form aromatic compounds. The central place of aromatic compounds in both medicinal chemistry and natural products synthesis, coupled with the efficiency and functional group tolerance of RCM catalysts, means that there is now an interesting opportunity to use ...

Expand abstract

Authors: Donohoe, T; Orr, A; Bingham, M

• Publication status: Published
• Journal: Angewandte Chemie (International ed. in English)
• Volume: 45
• Issue: 17
• Pages: 2664-2670
• Publication date: 2006-04-01
• DOI: 10.1002/anie.200503512
• EISSN: 1521-3773
• ISSN: 1433-7851
• Language: English
• Keywords: Pyrroles; Oxidation-Reduction; Cyclization; Molecular Structure; Models, Chemical; Isomerism