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Journal article

Reproducibility and replicability of rodent phenotyping in preclinical studies

Abstract:

The scientific community is increasingly concerned with the proportion of published "discoveries" that are not replicated in subsequent studies. The field of rodent behavioral phenotyping was one of the first to raise this concern, and to relate it to other methodological issues: the complex interaction between genotype and environment; the definitions of behavioral constructs; and the use of laboratory mice and rats as model species for investigating human health and disease mechanisms. In J...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1016/j.neubiorev.2018.01.003

Authors


Kafkafi, N More by this author
Chesler, EJ More by this author
Crabbe, JC More by this author
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ORCID:
0000-0001-6638-202X
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Publisher:
Elsevier Publisher's website
Journal:
Neuroscience and biobehavioral reviews Journal website
Volume:
87
Pages:
218-232
Publication date:
2018-01-31
Acceptance date:
2018-01-11
DOI:
EISSN:
1873-7528
ISSN:
0149-7634
Pubs id:
pubs:821311
URN:
uri:6963ae42-d81b-4c19-9e28-085defdf59a5
UUID:
uuid:6963ae42-d81b-4c19-9e28-085defdf59a5
Local pid:
pubs:821311

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