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Diazepam effects on local cortical neural activity during sleep in mice

Abstract:

GABA-ergic neurotransmission plays a key role in sleep regulatory mechanisms and in brain oscillations during sleep. Benzodiazepines such as diazepam are known to induce sedation and promote sleep, however, EEG spectral power in slow frequencies is typically reduced after the administration of benzodiazepines or similar compounds. EEG slow waves arise from a synchronous alternation between periods of cortical network activity (ON) and silence (OFF), and represent a sensitive marker of precedi...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.bcp.2021.114515

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Institution:
University of Oxford
Division:
MSD
Sub department:
Physiology Anatomy & Genetics
Oxford college:
Balliol College
Role:
Author
ORCID:
0000-0002-4336-6681
Publisher:
Elsevier Publisher's website
Journal:
Biochemical Pharmacology Journal website
Volume:
191
Article number:
114515
Publication date:
2021-03-10
Acceptance date:
2021-03-04
DOI:
ISSN:
0006-2952
Language:
English
Keywords:
Pubs id:
1168031
Local pid:
pubs:1168031
Deposit date:
2021-04-03

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