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Cork-in-bottle occlusion of fluoride ion channels by crystallization chaperones

Abstract:

Crystallization of dual-topology fluoride (Fluc) channels requires small, soluble crystallization chaperones known as monobodies, which act as primary crystal lattice contacts. Previous structures of Flucs have been solved in the presence of monobodies that inhibit fluoride currents in single-channel electrophysiological recordings. These structures have revealed two-fold symmetric, doubly bound arrangements, with one monobody on each side of the membrane. The combined electrophysiological an...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.str.2018.02.004

Authors


McIlwain, BC More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Oxford college:
Christ Church
Stockbridge, RB More by this author
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Funding agency for:
Newstead, S
Publisher:
Cell Press Publisher's website
Journal:
Structure Journal website
Volume:
26
Issue:
4
Pages:
635-639
Publication date:
2018-03-08
Acceptance date:
2018-02-05
DOI:
EISSN:
1878-4186
ISSN:
0969-2126
Pubs id:
pubs:829885
URN:
uri:695e787a-fb9e-4ba0-a165-9de3a2ee727a
UUID:
uuid:695e787a-fb9e-4ba0-a165-9de3a2ee727a
Local pid:
pubs:829885
Language:
English
Keywords:

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