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Thesis

Structure of the RNA-dependent RNA polymerase from influenza C virus

Abstract:

The influenza virus causes a disease that kills approximately 500,000 people worldwide each year. Influenza is a negative-sense RNA virus that encodes its own RNA-dependent RNA polymerase. This protein (FluPol) carries out both genome replication and viral transcription. Therefore, like the L-proteins of non-segmented negative-sense RNA (nsRNA) viruses, FluPol also contains mRNA capping and polyadenylation functionality. In FluPol, capping is achieved by snatching cap structures from cellu...

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Oxford college:
Christ Church
Role:
Author

Contributors

Division:
MSD
Department:
Pathology Dunn School
Role:
Supervisor
Division:
MSD
Department:
Pathology Dunn School
Role:
Supervisor
More from this funder
Name:
Wellcome Trust
Funding agency for:
Hengrung, N
Grant:
092931/Z/10/Z
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:694e16a6-f94e-4375-a1f9-7e250aea7343
Local pid:
ora:11302
Deposit date:
2015-04-29

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