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Patterns of synaptic activity in neural networks recorded by light emission from synaptolucins.

Abstract:

The emission of light, coupled to exocytosis, can in principle be utilized to monitor the activity of a large number of individual synapses simultaneously. To illustrate this concept, fusion proteins of Cypridina luciferase and synaptotagmin-I or VAMP-2/synaptobrevin (which we term "synaptolucins") were expressed in cultured hippocampal neurons with the help of viral vectors. Synaptolucins were targeted to synaptic vesicles and, upon exocytosis, formed light-emitting complexes with their cogn...

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Publisher copy:
10.1073/pnas.94.7.3402
Journal:
Proceedings of the National Academy of Sciences of the United States of America More from this journal
Volume:
94
Issue:
7
Pages:
3402-3407
Publication date:
1997-04-01
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Language:
English
Keywords:
Pubs id:
pubs:322577
UUID:
uuid:694b21cb-9ba5-4b74-9345-4a8496d269e9
Local pid:
pubs:322577
Source identifiers:
322577
Deposit date:
2013-11-16

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