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Crystal structure of Porphyromonas gingivalis peptidylarginine deiminase: implications for autoimmunity in rheumatoid arthritis

Abstract:

Background Periodontitis (PD) is a known risk factor for rheumatoid arthritis (RA) and there is increasing evidence that the link between the two diseases is due to citrullination by the unique bacterial peptidylarginine deiminase (PAD) enzyme expressed by periodontal pathogen Pophyromonas gingivalis (PPAD). However, the precise mechanism by which PPAD could generate potentially immunogenic peptides has remained controversial due to lack of information about the structural and catalytic mecha...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1136/annrheumdis-2015-207656

Authors


Publisher:
BMJ Publishing Group
Journal:
Annals of the Rheumatic Diseases More from this journal
Volume:
75
Issue:
6
Pages:
1255-1261
Publication date:
2015-07-24
Acceptance date:
2015-07-06
DOI:
EISSN:
1468-2060
ISSN:
0003-4967
Pmid:
26209657
Keywords:
Pubs id:
pubs:720788
UUID:
uuid:6944c2a9-e1c6-4a1f-82b8-ea85eb3b80ee
Local pid:
pubs:720788
Source identifiers:
720788
Deposit date:
2017-08-18

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