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Journal article

CDC4 mutations occur in a subset of colorectal cancers but are not predicted to cause loss of function and are not associated with chromosomal instability.

Abstract:

CDC4/FBXW7 is part of a ubiquitin ligase complex which targets molecules such as cyclin E, c-myc, and c-jun for destruction. CDC4 mutations occur in several cancer types and are best described in colorectal tumors. Knockout of CDC4 in vitro in colorectal cancer cells causes changes suggestive of chromosomal instability (CIN). In p53(+/-) mice, radiation-induced lymphomas show deletion or mutation of one copy of CDC4 and knockdown of CDC4 leads to increased aneuploidy in mouse fibroblasts. We ...

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Publication status:
Published

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Authors


Chambers, W More by this author
Wortham, N More by this author
Halford, S More by this author
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Journal:
Cancer research
Volume:
65
Issue:
24
Pages:
11361-11366
Publication date:
2005-12-05
DOI:
EISSN:
1538-7445
ISSN:
0008-5472
URN:
uuid:6943a4dd-f81f-4d31-ab13-ba5d52892502
Source identifiers:
39737
Local pid:
pubs:39737

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