ESAM supports neutrophil extravasation, activation of Rho, and VEGF-induced vascular permeability.

Journal article

Endothelial cell-selective adhesion molecule (ESAM) is specifically expressed at endothelial tight junctions and on platelets. To test whether ESAM is involved in leukocyte extravasation, we have generated mice carrying a disrupted ESAM gene and analyzed them in three different inflammation models. We found that recruitment of lymphocytes into inflamed skin was unaffected by the gene disruption. However, the migration of neutrophils into chemically inflamed peritoneum was inhibited by 70% at ...

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Authors: Wegmann, F; Petri, B; Khandoga, A; Moser, C; Khandoga, A

• Publication status: Published
• Journal: Journal of experimental medicine
• Volume: 203
• Issue: 7
• Pages: 1671-1677
• Publication date: 2006-07-01
• DOI: 10.1084/jem.20060565
• EISSN: 1540-9538
• ISSN: 0022-1007
• Language: English
• Keywords: Animals; Enzyme Activation; Neutrophils; Mice; Cell Adhesion Molecules; Cell Communication; rho GTP-Binding Proteins; Capillary Permeability; Female; Male; Mice, Knockout; Cell Movement; Vascular Endothelial Growth Factor A