Journal article
Protection against ventricular fibrillation via cholinergic receptor stimulation and the generation of nitric oxide.
- Abstract:
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Implantable cardiac vagal nerve stimulators are a promising treatment for ventricular arrhythmia in patients with heart failure. Animal studies suggest the antifibrillatory effect may be nitric oxide (NO) dependent, although the exact site of action is controversial. We investigated whether a stable analogue of acetylcholine could raise ventricular fibrillation threshold (VFT), and whether this was dependent on NO generation and/or muscarinic/nicotinic receptor stimulation.VFT was determined ...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Version of record, pdf, 451.9KB)
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- Publisher copy:
- 10.1113/jp271588
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Authors
Funding
+ British Heart Foundation
More from this funder
Funding agency for:
Herring, N
Grant:
BHF Clinical
Intermediate Fellow (FS/15/8/31155
Bibliographic Details
- Publisher:
- John Wiley and Sons Ltd Publisher's website
- Journal:
- Journal of physiology Journal website
- Publication date:
- 2016-01-01
- DOI:
- EISSN:
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1469-7793
- ISSN:
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0022-3751
- Source identifiers:
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586546
Item Description
- Language:
- English
- Pubs id:
-
pubs:586546
- UUID:
-
uuid:69427ef7-2cdc-47c7-8499-3ae642ee8702
- Local pid:
- pubs:586546
- Deposit date:
- 2016-02-01
Terms of use
- Copyright holder:
- Kalla et al
- Copyright date:
- 2016
- Notes:
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Copyright © 2016 The Authors. The Journal of Physiology published by John Wiley and Sons Ltd on behalf of The Physiological Society
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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