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Protection against ventricular fibrillation via cholinergic receptor stimulation and the generation of nitric oxide.

Abstract:

Implantable cardiac vagal nerve stimulators are a promising treatment for ventricular arrhythmia in patients with heart failure. Animal studies suggest the antifibrillatory effect may be nitric oxide (NO) dependent, although the exact site of action is controversial. We investigated whether a stable analogue of acetylcholine could raise ventricular fibrillation threshold (VFT), and whether this was dependent on NO generation and/or muscarinic/nicotinic receptor stimulation.VFT was determined ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1113/jp271588

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
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Funding agency for:
Herring, N
Grant:
BHF Clinical Intermediate Fellow (FS/15/8/31155
Publisher:
John Wiley and Sons Ltd Publisher's website
Journal:
Journal of physiology Journal website
Publication date:
2016-01-01
DOI:
EISSN:
1469-7793
ISSN:
0022-3751
Source identifiers:
586546
Language:
English
Pubs id:
pubs:586546
UUID:
uuid:69427ef7-2cdc-47c7-8499-3ae642ee8702
Local pid:
pubs:586546
Deposit date:
2016-02-01

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