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Journal article

Gene expression and risk of leukemic transformation in myelodysplasia

Abstract:

Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal hematopoietic disorders with a highly variable prognosis. To identify a gene expression-based classification of myelodysplasia with biological and clinical relevance, we performed a comprehensive transcriptomic analysis of myeloid neoplasms with dysplasia using transcriptome sequencing. Unsupervised clustering of gene expression data of bone marrow CD34+ cells from 100 patients identified two subgroups. The first subtype was ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1182/blood-2017-05-783050

Authors


Shiozawa, Y More by this author
Malcovati, L More by this author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; RDM Clinical Laboratory Sciences
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Funding agency for:
Pellagatti, A
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Funding agency for:
Boultwood, J
Publisher:
American Society of Hematology Publisher's website
Journal:
Blood Journal website
Volume:
130
Issue:
24
Pages:
2642-2653
Publication date:
2017-11-02
Acceptance date:
2017-10-11
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
Pubs id:
pubs:743529
URN:
uri:693dab68-bc7e-4483-9453-894b6f54b202
UUID:
uuid:693dab68-bc7e-4483-9453-894b6f54b202
Local pid:
pubs:743529
Language:
English

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