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Journal article

Gene expression and risk of leukemic transformation in myelodysplasia

Abstract:

Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal hematopoietic disorders with a highly variable prognosis. To identify a gene expression-based classification of myelodysplasia with biological and clinical relevance, we performed a comprehensive transcriptomic analysis of myeloid neoplasms with dysplasia using transcriptome sequencing. Unsupervised clustering of gene expression data of bone marrow CD34+ cells from 100 patients identified two subgroups. The first subtype was ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1182/blood-2017-05-783050

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Clinical Laboratory Sciences
Role:
Author
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Funding agency for:
Pellagatti, A
Grant:
Specialist Programme (13042
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Funding agency for:
Boultwood, J
Grant:
Specialist Programme (13042
Publisher:
American Society of Hematology Publisher's website
Journal:
Blood Journal website
Volume:
130
Issue:
24
Pages:
2642-2653
Publication date:
2017-11-02
Acceptance date:
2017-10-11
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
Pmid:
29097382
Source identifiers:
743529
Language:
English
Pubs id:
pubs:743529
UUID:
uuid:693dab68-bc7e-4483-9453-894b6f54b202
Local pid:
pubs:743529
Deposit date:
2017-11-06

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