- Abstract:
-
Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal hematopoietic disorders with a highly variable prognosis. To identify a gene expression-based classification of myelodysplasia with biological and clinical relevance, we performed a comprehensive transcriptomic analysis of myeloid neoplasms with dysplasia using transcriptome sequencing. Unsupervised clustering of gene expression data of bone marrow CD34+ cells from 100 patients identified two subgroups. The first subtype was ...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Accepted Manuscript
- Files:
-
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(pdf, 102.4kb)
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(pdf, 21.0mb)
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(pdf, 1.9mb)
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(pdf, 253.9kb)
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(pdf, 203.6kb)
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(pdf, 51.3kb)
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- Publisher copy:
- 10.1182/blood-2017-05-783050
-
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- Publisher:
- American Society of Hematology Publisher's website
- Journal:
- Blood Journal website
- Volume:
- 130
- Issue:
- 24
- Pages:
- 2642-2653
- Publication date:
- 2017-11-02
- Acceptance date:
- 2017-10-11
- DOI:
- EISSN:
-
1528-0020
- ISSN:
-
0006-4971
- Pubs id:
-
pubs:743529
- URN:
-
uri:693dab68-bc7e-4483-9453-894b6f54b202
- UUID:
-
uuid:693dab68-bc7e-4483-9453-894b6f54b202
- Local pid:
- pubs:743529
- Language:
- English
- Copyright holder:
- American Society of Hematology
- Copyright date:
- 2017
- Notes:
-
Copyright © 2017 American Society of Hematology. This is the accepted manuscript version of the article. The final version is available online from the American Society of Hematology at: https://doi.org/10.1182/blood-2017-05-783050
Journal article
Gene expression and risk of leukemic transformation in myelodysplasia
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