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Re-engineering Caenorhabditis elegans SAS-6: from spirals to rings

Abstract:

Centrioles have conserved 9-fold symmetry. This symmetry is templated by a scaffold of SAS-6. SAS-6 oligomerises to form a stack of rings, each with 9-fold radial symmetry, that forms the cartwheel, which imparts symmetry to the organelle. However, crystallographic and electron microscopy studies suggest that C. elegans is unique in that it forms a spiral SAS-6 scaffold instead of a cartwheel. Thus, there are two competing architectures of SAS-6 scaffold. Inconclusive electron microscopy o...

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Division:
MSD
Department:
Biochemistry
Role:
Author

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Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
UUID:
uuid:693d14a1-e80a-4713-a6b2-21cabace0cf8
Deposit date:
2019-10-25

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