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HPV8 field cancerization in a transgenic mouse model Is due to Lrig1+ keratinocyte stem cell expansion

Abstract:

β-Human papillomaviruses (HPVs) cause near ubiquitous latent skin infection within long-lived hair follicle (HF) keratinocyte stem cells. In patients with epidermodysplasia verruciformis, β-HPV viral replication is associated with skin keratosis and cutaneous squamous cell carcinoma. To determine the role of HF keratinocyte stem cells in β-HPV-induced skin carcinogenesis, we utilized a transgenic mouse model in which the keratin 14 promoter drives expression of the entire HPV8 early region (H...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.jid.2017.04.039

Authors


Lanfredini, S More by this author
Olivero, C More by this author
Borgogna, C More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
NDM Experimental Medicine
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Publisher:
Elsevier Publisher's website
Journal:
Journal of Investigative Dermatology Journal website
Volume:
137
Issue:
10
Pages:
2208-2216
Publication date:
2017-06-06
Acceptance date:
2017-04-28
DOI:
EISSN:
1523-1747
ISSN:
0022-202X
Pubs id:
pubs:797819
URN:
uri:69399bdf-1f4d-43e1-8b12-713a7f1d4abe
UUID:
uuid:69399bdf-1f4d-43e1-8b12-713a7f1d4abe
Local pid:
pubs:797819

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