Journal article
HPV8 field cancerization in a transgenic mouse model Is due to Lrig1+ keratinocyte stem cell expansion
- Abstract:
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β-Human papillomaviruses (HPVs) cause near ubiquitous latent skin infection within long-lived hair follicle (HF) keratinocyte stem cells. In patients with epidermodysplasia verruciformis, β-HPV viral replication is associated with skin keratosis and cutaneous squamous cell carcinoma. To determine the role of HF keratinocyte stem cells in β-HPV-induced skin carcinogenesis, we utilized a transgenic mouse model in which the keratin 14 promoter drives expression of the entire HPV8 early region (H...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
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- Files:
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(pdf, 3.3MB)
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- Publisher copy:
- 10.1016/j.jid.2017.04.039
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Authors
Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Journal of Investigative Dermatology Journal website
- Volume:
- 137
- Issue:
- 10
- Pages:
- 2208-2216
- Publication date:
- 2017-06-06
- Acceptance date:
- 2017-04-28
- DOI:
- EISSN:
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1523-1747
- ISSN:
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0022-202X
- Pubs id:
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pubs:797819
- URN:
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uri:69399bdf-1f4d-43e1-8b12-713a7f1d4abe
- UUID:
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uuid:69399bdf-1f4d-43e1-8b12-713a7f1d4abe
- Local pid:
- pubs:797819
Item Description
Terms of use
- Copyright holder:
- Lanfredini et al
- Copyright date:
- 2017
- Notes:
- © 2017 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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