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Journal article

Co-localisation of the Kir6.2/SUR1 channel complex with glucagon-like peptide-1 and glucose-dependent insulinotrophic polypeptide expression in human ileal cells and implications for glycaemic control in new onset type 1 diabetes.

Abstract:

OBJECTIVE: The ATP-dependent K+-channel (K(ATP)) is critical for glucose sensing and normal glucagon and insulin secretion from pancreatic endocrine alpha- and beta-cells. Gastrointestinal endocrine L- and K-cells are also glucose-sensing cells secreting glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotrophic polypeptide (GIP) respectively. The aims of this study were to 1) investigate the expression and co-localisation of the K(ATP) channel subunits, Kir6.2 and SUR1, in human ...

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Publication status:
Published

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Publisher copy:
10.1530/eje-06-0756

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Journal:
European journal of endocrinology / European Federation of Endocrine Societies
Volume:
156
Issue:
6
Pages:
663-671
Publication date:
2007-06-05
DOI:
EISSN:
1479-683X
ISSN:
0804-4643
URN:
uuid:69368933-b92d-4415-ac2e-7c2d073cedff
Source identifiers:
16274
Local pid:
pubs:16274

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