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Overcoming acquired resistance to letrozole by targeting the PI3K/AKT/mTOR pathway in breast cancer cell clones

Abstract:

Development of resistance to endocrine therapy is a clinical issue in estrogen receptor (ER)-positive breast cancer. Here we show that persistent activation of AKT/mTOR signaling is crucial to the acquisition of letrozole resistance in cell clones generated from MCF-7/AROM-1 aromatase-expressing breast cancer cells after prolonged letrozole exposure. ERα plays a marginal role in this context. As a proof of concept, the association between PI3K/AKT/mTOR signaling and insensitivity to endocrine...

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Journal:
Cancer Letters More from this journal
Volume:
323
Issue:
1
Pages:
77-87
Publication date:
2012-10-01
DOI:
EISSN:
1872-7980
ISSN:
0304-3835
Language:
English
Keywords:
Pubs id:
pubs:340206
UUID:
uuid:692ab9f5-d892-4347-bb91-27827d5daf9d
Local pid:
pubs:340206
Source identifiers:
340206
Deposit date:
2013-11-16

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