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The potential for improving cardio-renal outcomes by sodium-glucose co-transporter-2 inhibition in people with chronic kidney disease: a rationale for the EMPA-KIDNEY study

Abstract:

Diabetes is a common cause of chronic kidney disease (CKD), but in aggregate, non-diabetic diseases account for a higher proportion of cases of CKD than diabetes in many parts of the world. Inhibition of the renin–angiotensin system reduces the risk of kidney disease progression and treatments that lower blood pressure (BP) or low-density lipoprotein cholesterol reduce cardiovascular (CV) risk in this population. Nevertheless, despite such interventions, considerable risks for kidney and CV c...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1093/ckj/sfy090

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Nuffield Dept of Population Health
Subgroup:
Clinical Trial Service Unit
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Nuffield Dept of Population Health
Subgroup:
Clinical Trial Service Unit
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Nuffield Dept of Population Health
Subgroup:
Clinical Trial Service Unit
von Eynatten, M More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Nuffield Dept of Population Health
Subgroup:
Clinical Trial Service Unit
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More from this funder
Funding agency for:
Herrington, WG
More from this funder
Funding agency for:
Herrington, WG
Publisher:
Oxford University Press Publisher's website
Journal:
Clinical Kidney Journal Journal website
Volume:
11
Issue:
6
Pages:
749–761
Publication date:
2018-10-25
Acceptance date:
2018-08-24
DOI:
EISSN:
2048-8513
ISSN:
2048-8505
Pubs id:
pubs:923310
URN:
uri:6921189b-3226-4398-848d-a679f8d6e0da
UUID:
uuid:6921189b-3226-4398-848d-a679f8d6e0da
Local pid:
pubs:923310

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