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Expression of 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue is not increased in human obesity.

Abstract:

Central obesity is associated with increased morbidity and mortality. Preadipocyte proliferation and differentiation contribute to increases in adipose tissue mass, yet the mechanisms that underlie these processes remain unclear. Patients with glucocorticoid excess develop a reversible form of central obesity, but circulating cortisol levels in idiopathic obesity are invariably normal. We have hypothesized that the enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1), by converting...

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Publication status:
Published

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Publisher copy:
10.1210/jc.2002-020687

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Role:
Author
Journal:
Journal of clinical endocrinology and metabolism More from this journal
Volume:
87
Issue:
12
Pages:
5630-5635
Publication date:
2002-12-01
DOI:
EISSN:
1945-7197
ISSN:
0021-972X
Language:
English
Keywords:
Pubs id:
pubs:482110
UUID:
uuid:691d87f2-16e0-4df5-aa22-ec0a6b2ecf25
Local pid:
pubs:482110
Source identifiers:
482110
Deposit date:
2014-08-29

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