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The interplay between membrane topology and mechanical forces in regulating T cell receptor activity

Abstract:

T cells are critically important for host defense against infections. T cell activation is specific because signal initiation requires T cell receptor (TCR) recognition of foreign antigen peptides presented by major histocompatibility complexes (pMHC) on antigen presenting cells (APCs). Recent advances reveal that the TCR acts as a mechanoreceptor, but it remains unclear how pMHC/TCR engagement generates mechanical forces that are converted to intracellular signals. Here we propose a TCR Bend...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s42003-021-02995-1

Authors


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Role:
Author
ORCID:
0000-0002-0520-979X
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Role:
Author
ORCID:
0000-0003-3523-1477
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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Author
ORCID:
0000-0003-4983-6389
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Role:
Author
ORCID:
0000-0003-2543-7295
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Name:
Ministry of Science and Technology, Taiwan
Publisher:
Springer Nature
Journal:
Communications Biology More from this journal
Volume:
5
Issue:
1
Article number:
40
Publication date:
2022-01-11
Acceptance date:
2021-12-21
DOI:
EISSN:
2399-3642
Pmid:
35017678
Language:
English
Keywords:
Subtype:
Review
Pubs id:
1236016
Local pid:
pubs:1236016
Deposit date:
2022-03-14

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