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A new approach of modified submerged patch clamp recording reveals interneuronal dynamics during Epileptiform oscillations

Abstract:

Highlights: Simultaneous epileptiform LFPs and single-cell activity can be recorded in the membrane chamber.Interneuron firing can be linked to epileptiform high frequency activity.Fast ripples, unique to chronic epilepsy, can be modeled in ex vivo tissue from TeNT-treated rats. Traditionally, visually-guided patch clamp in brain slices using submerged recording conditions has been required to characterize the activity of individual neurons. However, due to limited oxygen availability, submer...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.3389/fnins.2016.00519

Authors


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Role:
Author
ORCID:
0000-0003-2469-5102
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Role:
Author
ORCID:
0000-0003-4955-8577
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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
ORCID:
0000-0003-0106-4412
More from this funder
Funding agency for:
Jefferys, J
Grant:
P1102
Publisher:
Frontiers Media Publisher's website
Journal:
Frontiers in Neuroscience Journal website
Volume:
10
Publication date:
2016-11-09
Acceptance date:
2016-10-26
DOI:
EISSN:
1662-453X
ISSN:
1662-4548
Pmid:
27881950
Language:
English
Keywords:
Pubs id:
pubs:664406
UUID:
uuid:691a4536-5d2b-480b-86c9-eb659d15fdc5
Local pid:
pubs:664406
Source identifiers:
664406
Deposit date:
2018-08-17

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