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Derepression of microRNA-138 contributes to loss of the human articular chondrocyte phenotype

Abstract:

To investigate the function of microRNA-138 (miR-138) in human articular chondrocytes (HACs).The expression of miR-138 in intact cartilage and cultured chondrocytes and the effects of miR-138 overexpression on chondrocyte marker genes were investigated. Targets of miR-138 relevant to chondrocytes were identified and verified by overexpression of synthetic miRNA mimics and inhibitors, luciferase assays, chromatin immunoprecipitation, and RNA immunoprecipitation of native argonaute 2, using qua...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/art.39428

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Author
Arthritis Research UK More from this funder
Publisher:
Wiley Publisher's website
Journal:
Arthritis & Rheumatology
Volume:
68
Issue:
2
Pages:
398–409
Publication date:
2016-01-29
Acceptance date:
2015-09-03
DOI:
ISSN:
2326-5205 and 2326-5191
Pmid:
26359943

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