Journal article
Derepression of microRNA-138 contributes to loss of the human articular chondrocyte phenotype
- Abstract:
-
To investigate the function of microRNA-138 (miR-138) in human articular chondrocytes (HACs).The expression of miR-138 in intact cartilage and cultured chondrocytes and the effects of miR-138 overexpression on chondrocyte marker genes were investigated. Targets of miR-138 relevant to chondrocytes were identified and verified by overexpression of synthetic miRNA mimics and inhibitors, luciferase assays, chromatin immunoprecipitation, and RNA immunoprecipitation of native argonaute 2, using qua...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Publisher copy:
- 10.1002/art.39428
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Authors
Funding
Arthritis Research UK
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Bibliographic Details
- Publisher:
- Wiley Publisher's website
- Journal:
- Arthritis & Rheumatology
- Volume:
- 68
- Issue:
- 2
- Pages:
- 398–409
- Publication date:
- 2016-01-29
- Acceptance date:
- 2015-09-03
- DOI:
- ISSN:
-
2326-5205 and 2326-5191
- Pmid:
-
26359943
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:612205
- UUID:
-
uuid:691806a9-6979-448f-8b7b-1f613b55a08a
- Local pid:
- pubs:612205
- Deposit date:
- 2016-10-17
Terms of use
- Copyright holder:
- American College of Rheumatology
- Copyright date:
- 2016
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