Journal article icon

Journal article

Derepression of microRNA-138 contributes to loss of the human articular chondrocyte phenotype

Abstract:

To investigate the function of microRNA-138 (miR-138) in human articular chondrocytes (HACs).The expression of miR-138 in intact cartilage and cultured chondrocytes and the effects of miR-138 overexpression on chondrocyte marker genes were investigated. Targets of miR-138 relevant to chondrocytes were identified and verified by overexpression of synthetic miRNA mimics and inhibitors, luciferase assays, chromatin immunoprecipitation, and RNA immunoprecipitation of native argonaute 2, using qua...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Publisher copy:
10.1002/art.39428

Authors


Martinez-Sanchez, A More by this author
More by this author
Department:
Oxford, MSD, NDORMS, KIR
Arthritis Research UK More from this funder
Publisher:
Wiley Online Library Publisher's website
Journal:
Arthritis & Rheumatology
Volume:
68
Issue:
2
Pages:
398–409
Publication date:
2016-01-29
Acceptance date:
2015-09-03
DOI:
ISSN:
2326-5205 and 2326-5191
Pubs id:
pubs:612205
URN:
uri:691806a9-6979-448f-8b7b-1f613b55a08a
UUID:
uuid:691806a9-6979-448f-8b7b-1f613b55a08a
Local pid:
pubs:612205
Paper number:
2

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP