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HIF-1 reduces ischaemia-reperfusion injury in the heart by targeting the mitochondrial permeability transition pore.

Abstract:

AIMS: Hypoxia-inducible factor-1 (HIF-1) has been reported to promote tolerance against acute myocardial ischaemia-reperfusion injury (IRI). However, the mechanism through which HIF-1 stabilization actually confers this cardioprotection is not clear. We investigated whether HIF-1α stabilization protects the heart against acute IRI by preventing the opening of the mitochondrial permeability transition pore (MPTP) and the potential mechanisms involved. METHODS AND RESULTS: Stabilization of myoc...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1093/cvr/cvu172

Authors


Theodorou, L More by this author
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Grant:
RG/03/007; FS/10/039/28270
Publisher:
Oxford University Press Publisher's website
Journal:
Cardiovascular research Journal website
Volume:
104
Issue:
1
Pages:
24-36
Publication date:
2014-10-05
DOI:
EISSN:
1755-3245
ISSN:
0008-6363
URN:
uuid:691741dc-a1e3-4725-b5bc-1aefec3889c8
Source identifiers:
477694
Local pid:
pubs:477694

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