Journal article icon

Journal article

Treatment of a low grade T cell proliferation with monoclonal antibody.

Abstract:

A therapeutic trial of a pan-T monoclonal antibody is described in a patient with a low grade mature T cell proliferation and haemopoietic suppression. The study shows that non-complement fixing IgG1 antibodies can be highly effective opsonins, and the dose required can be estimated from in vitro studies. It is demonstrated that therapeutic failure occurred due to the appearance of anti-mouse antibodies and not to antigenic modulation or reticuloendothelial blockade. The literature is reviewe...

Expand abstract

Actions


Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Role:
Author
Journal:
Clinical and experimental immunology
Volume:
51
Issue:
1
Pages:
133-140
Publication date:
1983-01-05
EISSN:
1365-2249
ISSN:
0009-9104
URN:
uuid:6910d24d-ce6b-4206-be48-30dfa22b8954
Source identifiers:
35508
Local pid:
pubs:35508

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP