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Epigenetic silencing of HNF1A associates with changes in the composition of the human plasma N-glycome.

Abstract:

Protein glycosylation is a ubiquitous modification that affects the structure and function of proteins. Our recent genome wide association study identified transcription factor HNF1A as an important regulator of plasma protein glycosylation. To evaluate the potential impact of epigenetic regulation of HNF1A on protein glycosylation we analyzed CpG methylation in 810 individuals. The association between methylation of four CpG sites and the composition of plasma and IgG glycomes was analyzed. ...

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Publication status:
Published

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Publisher copy:
10.4161/epi.7.2.18918

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Journal:
Epigenetics : official journal of the DNA Methylation Society More from this journal
Volume:
7
Issue:
2
Pages:
164-172
Publication date:
2012-02-01
DOI:
EISSN:
1559-2308
ISSN:
1559-2294
Language:
English
Keywords:
Pubs id:
pubs:314338
UUID:
uuid:69050ba9-0357-4ef7-adbd-00500327c84d
Local pid:
pubs:314338
Source identifiers:
314338
Deposit date:
2012-12-19

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