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Direct determination by 2H-NMR of the ionization state of phospholipids and of a local anaesthetic at the membrane surface.

Abstract:

Protonation and deprotonation of the primary amino group of phosphatidylethanolamine, and of the lipid phosphate groups of phosphatidylethanolamine with phosphatidylcholine, have been observed directly and isothermally in equimolar mixed fluid bilayers of the two phospholipids. In addition, the acid-base titration of the secondary amino group of the local anaesthetic, tetracaine, whilst partitioned into the bilayers, has also been determined. Here we show how studies by deuterium nuclear magn...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
Journal:
Biochimica et biophysica acta More from this journal
Volume:
861
Issue:
2
Pages:
368-372
Publication date:
1986-10-01
DOI:
ISSN:
0006-3002
Language:
English
Keywords:
Pubs id:
pubs:422219
UUID:
uuid:6902be00-48e5-4409-9205-6e9cfb2d43e2
Local pid:
pubs:422219
Source identifiers:
422219
Deposit date:
2013-11-17

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