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Journal article

Early gene regulation of osteogenesis in embryonic stem cells.

Abstract:

The early gene regulatory networks (GRNs) that mediate stem cell differentiation are complex, and the underlying regulatory associations can be difficult to map accurately. In this study, the expression profiles of the genes Dlx5, Msx2 and Runx2 in mouse embryonic stem cells were monitored over a 48 hour period after exposure to the growth factors BMP2 and TGFβ1. Candidate GRNs of early osteogenesis were constructed based on published experimental findings and simulation results of Boolean an...

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Publication status:
Published

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Publisher copy:
10.1039/c2ib20164j

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Institution:
University of Oxford
Division:
MPLS
Department:
Mathematical Institute
Role:
Author
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Journal:
Integrative biology : quantitative biosciences from nano to macro
Volume:
4
Issue:
12
Pages:
1470-1477
Publication date:
2012-12-01
DOI:
EISSN:
1757-9708
ISSN:
1757-9694
Source identifiers:
354061

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