Journal article
Early gene regulation of osteogenesis in embryonic stem cells.
- Abstract:
-
The early gene regulatory networks (GRNs) that mediate stem cell differentiation are complex, and the underlying regulatory associations can be difficult to map accurately. In this study, the expression profiles of the genes Dlx5, Msx2 and Runx2 in mouse embryonic stem cells were monitored over a 48 hour period after exposure to the growth factors BMP2 and TGFβ1. Candidate GRNs of early osteogenesis were constructed based on published experimental findings and simulation results of Boolean an...
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- Publication status:
- Published
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- Publisher copy:
- 10.1039/c2ib20164j
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Bibliographic Details
- Journal:
- Integrative biology : quantitative biosciences from nano to macro
- Volume:
- 4
- Issue:
- 12
- Pages:
- 1470-1477
- Publication date:
- 2012-12-01
- DOI:
- EISSN:
-
1757-9708
- ISSN:
-
1757-9694
- Source identifiers:
-
354061
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:354061
- UUID:
-
uuid:6902325d-a954-443e-b38a-c236a1eeeafd
- Local pid:
- pubs:354061
- Deposit date:
- 2013-11-16
Terms of use
- Copyright date:
- 2012
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