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Safety and immunogenicity of a candidate tuberculosis vaccine MVA85A delivered by aerosol in BCG-vaccinated healthy adults: a phase 1, double-blind, randomised controlled trial.

Abstract:

BACKGROUND: Intradermal MVA85A, a candidate vaccine against tuberculosis, induces high amounts of Ag85A-specific CD4 T cells in adults who have already received the BCG vaccine, but aerosol delivery of this vaccine might offer immunological and logistical advantages. We did a phase 1 double-blind trial to compare the safety and immunogenicity of aerosol-administered and intradermally administered MVA85A METHODS: In this phase 1, double-blind, proof-of-concept trial, 24 eligible BCG-vaccinated...

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Publication status:
Published

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Authors


Harris, SA More by this author
Manjaly Thomas, ZR More by this author
Griffiths, K More by this author
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Journal:
The Lancet. Infectious diseases
Volume:
14
Issue:
10
Pages:
939-946
Publication date:
2014-10-05
DOI:
EISSN:
1474-4457
ISSN:
1473-3099
URN:
uuid:68ff0934-08a8-4179-9689-baba0996afc7
Source identifiers:
482203
Local pid:
pubs:482203
Language:
English

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