Essential amino acid depletion by embryonic stem cells as a mechanism of immune privilege
Mouse embryonic stem cells (ESCs) are capable of differentiating into any somatic cell type and are known to display fragile immune privilege in vivo and in vitro. The extent to which the depletion of essential amino acids (EAAs) by ESCs contributes to this phenomenon was investigated.
ESCs were found to express various enzymes capable of catabolising EAAs within the culture medium. In particular, depletion of threonine, valine and lysine was found to have signific...Expand abstract
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- Oxford University, UK
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- Copyright holder:
- Naoki Ichiryu
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- This thesis is not currently available in ORA.
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