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Thesis

Essential amino acid depletion by embryonic stem cells as a mechanism of immune privilege

Abstract:

Mouse embryonic stem cells (ESCs) are capable of differentiating into any somatic cell type and are known to display fragile immune privilege in vivo and in vitro. The extent to which the depletion of essential amino acids (EAAs) by ESCs contributes to this phenomenon was investigated.

ESCs were found to express various enzymes capable of catabolising EAAs within the culture medium. In particular, depletion of threonine, valine and lysine was found to have signific...

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Institution:
University of Oxford
Oxford college:
Lincoln College
Department:
Medical Sciences Division - Pathology

Contributors

Role:
Supervisor
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:68fe0c58-03d2-4ba0-af62-461a04a3e9d6
Local pid:
ora:9027

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