Thesis
Essential amino acid depletion by embryonic stem cells as a mechanism of immune privilege
- Abstract:
-
Mouse embryonic stem cells (ESCs) are capable of differentiating into any somatic cell type and are known to display fragile immune privilege in vivo and in vitro. The extent to which the depletion of essential amino acids (EAAs) by ESCs contributes to this phenomenon was investigated.
ESCs were found to express various enzymes capable of catabolising EAAs within the culture medium. In particular, depletion of threonine, valine and lysine was found to have signific...
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Bibliographic Details
- Publication date:
- 2013
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- Oxford University, UK
- URN:
-
uuid:68fe0c58-03d2-4ba0-af62-461a04a3e9d6
- Local pid:
- ora:9027
Item Description
- Language:
- English
- Keywords:
- Subjects:
Terms of use
- Copyright holder:
- Naoki Ichiryu
- Copyright date:
- 2013
- Notes:
- This thesis is not currently available in ORA.
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