Journal article icon

Journal article

Anti-caspase-3 preconditioning increases proinsulin secretion and deteriorates posttransplant function of isolated human islets.

Abstract:

Human islet isolation is associated with adverse conditions inducing apoptosis and necrosis. The aim of the present study was to assess whether antiapoptotic preconditioning can improve in vitro and posttransplant function of isolated human islets. A dose-finding study demonstrated that 200 μmol/L of the caspase-3 inhibitor Ac-DEVD-CMK was most efficient to reduce the expression of activated caspase-3 in isolated human islets exposed to severe heat shock. Ac-DEVD-CMK-pretreated or sham-treate...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1007/s10495-013-0834-6

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences
Role:
Author
Journal:
Apoptosis : an international journal on programmed cell death
Volume:
18
Issue:
6
Pages:
681-688
Publication date:
2013-06-05
DOI:
EISSN:
1573-675X
ISSN:
1360-8185
URN:
uuid:68fa7ca2-fa5f-4074-914c-c4cfbce7f154
Source identifiers:
383061
Local pid:
pubs:383061

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP