Journal article
Anti-caspase-3 preconditioning increases proinsulin secretion and deteriorates posttransplant function of isolated human islets.
- Abstract:
-
Human islet isolation is associated with adverse conditions inducing apoptosis and necrosis. The aim of the present study was to assess whether antiapoptotic preconditioning can improve in vitro and posttransplant function of isolated human islets. A dose-finding study demonstrated that 200 μmol/L of the caspase-3 inhibitor Ac-DEVD-CMK was most efficient to reduce the expression of activated caspase-3 in isolated human islets exposed to severe heat shock. Ac-DEVD-CMK-pretreated or sham-treate...
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- Publication status:
- Published
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- Publisher copy:
- 10.1007/s10495-013-0834-6
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Bibliographic Details
- Journal:
- Apoptosis : an international journal on programmed cell death
- Volume:
- 18
- Issue:
- 6
- Pages:
- 681-688
- Publication date:
- 2013-06-01
- DOI:
- EISSN:
-
1573-675X
- ISSN:
-
1360-8185
- Source identifiers:
-
383061
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:383061
- UUID:
-
uuid:68fa7ca2-fa5f-4074-914c-c4cfbce7f154
- Local pid:
- pubs:383061
- Deposit date:
- 2013-11-16
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- Copyright date:
- 2013
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