- Abstract:
-
Human islet isolation is associated with adverse conditions inducing apoptosis and necrosis. The aim of the present study was to assess whether antiapoptotic preconditioning can improve in vitro and posttransplant function of isolated human islets. A dose-finding study demonstrated that 200 μmol/L of the caspase-3 inhibitor Ac-DEVD-CMK was most efficient to reduce the expression of activated caspase-3 in isolated human islets exposed to severe heat shock. Ac-DEVD-CMK-pretreated or sham-treate...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1007/s10495-013-0834-6
-
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- Journal:
- Apoptosis : an international journal on programmed cell death
- Volume:
- 18
- Issue:
- 6
- Pages:
- 681-688
- Publication date:
- 2013-06-05
- DOI:
- EISSN:
-
1573-675X
- ISSN:
-
1360-8185
- URN:
-
uuid:68fa7ca2-fa5f-4074-914c-c4cfbce7f154
- Source identifiers:
-
383061
- Local pid:
- pubs:383061
- Language:
- English
- Keywords:
- Copyright date:
- 2013
Journal article
Anti-caspase-3 preconditioning increases proinsulin secretion and deteriorates posttransplant function of isolated human islets.
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